For your patients with minor
osteoarthritis (OA) pain,

Consider the strength of Aleve® for uninterrupted pain relief.

The growing body of evidence shows Aleve® is proven to provide tough pain relief1-4

Aleve® vs HYD+APAP

In a single-dose dental study, Aleve® was as strong* on pain as hydrocodone plus acetaminophen (HYD+APAP) and longer lasting.4

*In hours 0 to 4 of a single-dose dental study of Aleve® (440 mg), HYD+APAP (10 mg + 650 mg), or placebo.

Aleve® vs a different opioid combination

In 2 separate, single-dose dental studies, Aleve® was as strong on pain as acetaminophen plus codeine and longer lasting.5

Aleve® vs Tylenol®

Aleve® was proven more effective and to last longer on pain than Tylenol®.

Aleve® vs ibuprofen

In 2 identical, nonprescription dose studies in patients with OA of the knee, Aleve® provided more effective relief of pain at night than ibuprofen.6,†

†Patients with mild to moderate OA of the knee were randomized to daily doses of naproxen sodium 660 mg, naproxen sodium 440 mg, ibuprofen 1200 mg, or placebo.

Major guidelines recommend NSAIDs, like Aleve®, first line for OA pain.

Aleve® is the #1 orthopedic surgeon–recommended OTC brand for minor arthritis pain.5

bar chart showing Aleve® vs placebo in 6 endpoints
  • Aleve® provided significant pain relief across all efficacy endpoints (P<0.05)‡
  • Aleve® also provided significantly greater pain relief§ for patients ≥65 years of age (P<0.05)‡ for:
    • Pain on passive motion
    • Pain during the day and pain at night
    • Pain on weight bearing
    • Proven efficacy across multiple studies
Aleve® bottle and 12 hour badge

Aleve® targets pain from inflammation, giving your patients powerful, long-lasting, and uninterrupted relief.

Major guidelines recommend NSAIDs like naproxen, the active ingredient in Aleve®, as a first-line treatment of OA pain.

American Academy of Orthopaedic Surgeons7

  • Strongly recommends for knee OA pain7

American College of Rheumatology8

  • Strongly recommends for knee, hip, and/or hand OA8
    • Acetaminophen is conditionally recommended for patients with knee, hip, and/or hand OA

Aleve® is an OTC pain reliever indicated for temporary relief of minor aches and pains including arthritis pain, headache, muscular aches, and toothache.9

‡Results of a post hoc pooled analysis evaluating the efficacy and safety of Aleve® for short-term use in patients with OA of the knee or hip. In 4 multicenter, multidose, randomized, parallel, double-blind, placebo-controlled studies, Aleve® (age-based dosing regimen: <65 years, 660 mg/day; ≥65 years, 440 mg/day) or placebo was administered over 7 days. Data at baseline and after 7 days in 818 patients who received Aleve® or placebo (n=409 in each group) were pooled and analyzed.1

§Compared with placebo.

References: 1. Couto A, Troullos E, Moon J, Paredes-Diaz A, An R. Analgesic efficacy and safety of non-prescription doses of naproxen sodium in the management of moderate osteoarthritis of the knee or hip. Curr Med Res Opin. 2018;34(10):1747-1753. doi:10.1080/03007995.2018.1437029 2. Kiersch TA, Halladay SC, Hormel PC. A single-dose, double-blind comparison of naproxen sodium, acetaminophen, and placebo in postoperative dental pain. Clin Ther. 1994;16(3):394-404. 3. Daniels SE, Paredes-Diaz A, An R, Centofanti R, Tajaddini A. Significant, long-lasting pain relief in primary dysmenorrhea with low-dose naproxen sodium compared with acetaminophen: a double-blind, randomized, single-dose, crossover study. Curr Med Res Opin. 2019;35(12):2139-2147. doi:10.1080/03007995.2019.1654987 4. Cooper SA, Desjardins PJ, Bertoch T, et al. Analgesic efficacy of naproxen sodium versus hydrocodone/acetaminophen in acute postsurgical dental pain: a randomized, double-blind, placebo-controlled trial. Postgrad Med. 2021. doi:10.1080/00325481.2021.2008180 5. Data on file. Bayer Consumer Health. 6. Schiff M, Minic M. Comparison of the analgesic efficacy and safety of nonprescription doses of naproxen sodium and ibuprofen in the treatment of osteoarthritis of the knee. J Rheumatol. 2004;31(7):1373-1383. 7. American Academy of Orthopaedic Surgeons. Management of osteoarthritis of the knee (non-arthroplasty). Evidence-based clinical practice guideline. May 1, 2022. Accessed June 15, 2023. https://journals.lww.com/jaaos/Fulltext/2022/05010/AAOS_Clinical_Practice_Guideline_Summary_.10.aspx 8. Kolasinski SL, Neogi T, Hochberg MC, et al. 2019 American College of Rheumatology/Arthritis Foundation guideline for the management of osteoarthritis of the hand, hip, and knee. Arthritis Rheumatol. 2020;72(2): 220-233. doi:10.1002/art.41142 9. Aleve® Caplets. Drug facts. Bayer HealthCare; June 2022.